With the advent of the Human Genome Project, bioinformatics has not only played a supporting but also a crucial role in enabling next generation clinical genomics. However, translational medicine is vital since there is a big gap between bioinformatics research and medicine.
In addition, poor population-specific databases, processing large-scale robust genomic data, effective protocol establishment and validation in various areas of translational research, interpreting the functional impact of genomic variation, and making it all clinically relevant and understandable are some of the major challenges that must be addressed.
GenepoweRx, a prominent genomic data analysis firm situated in Hyderabad, has been exploiting the applicability of sequencing technology with the assistance of bioinformatics to reach out to the common man in the form of tailored medicine. The firm provides genomic reports based on an individual's genetic composition and recommends medicinal remedies based on biomarkers.
GenepoweRx collaborates on research with the National Institutes of Health, the American College of Medical Genomics and Genetics, PGRN and CPIC. Furthermore, the firm is supported by a diverse team with clinical and fundamental research experience in related fields such as molecular biology, genetics, bioinformatics, pharmacogenomics, clinical pharmacology, statistics, and artificial intelligence.
“For patients, we create clinically actionable reports that include illness risk stratification, pharmacogenomic reports, nutrigenomics, fitness, immunity profile, and diet plan. We have patented the procedure of annotating complicated genetic
data into therapeutic advice,” says Dr. Kalyan Uppaluri, Co-Founder, GenepoweRx. “We extensively use artificial intelligence and deep technology to generate accurate genome reports. To make the genetic data stronger, we have created a software platform performing secondary validation using information from multiple globally reputed databases such as genomAD, Clinvar, Clingen, ENSEMBL, MSK, and PharmaGKB,” he adds.
A Robust Medical Treatment
GenepoweRx is well-known in the market for cancer screening, pharmacogenomics, coronary artery disease genetic risk assessment, metabolic disorders profiling (diabetes, high blood pressure management, lipid disorders diagnosis and treatment), and other applications. GenepoweRx also provides a comprehensive overall health picture of an individual, as well as fitness, nutrigenomics profiles, and blood variables. It also examines the genetic risk of dementia, kidney stone, Parkinson's disease, heart disease, and other diseases.
All of these services are provided with the goal of bridging the gap between molecular technology, molecular diagnostics, and clinical application in order to make customized medicine a reality for everyone on the planet. Further, GenepoweRx ensures clinician friendly genomic report, with patient-friendly clinic that is backed by internationally accredited physician’s consultation. Internal validation with emphasis on Indian databases is carried out to ensure strict quality standards.
Dr. Kalyan Uppaluri, Co-Founder
“We have many case studies to our credit where the patient went back with hope and peace. Many of these revolve around identifying the right medication, reducing medication use, and preventing side effects, transitioning a patient from a disease state to a healthy state, providing the right guidance using genomics, identifying the root cause and triggers of the random symptoms expressed by the patient, early intervention and lifestyle modifications based on the genomics profile to prevent metabolic diseases, and guiding patients based on their genome representation, among others,” highlights Dr. Hima J Challa, Co-Founder & MD of the company.
As with much development in the genomics industry in terms of making testing more accessible to patients, there is a tremendous increase in the number of physicians and patients turning to genetic tests for customized medicine. GenepoweRx has positioned itself at the forefront of the creation of a complete clinical decision support system that simplifies genomics reports while allowing clinicians throughout the country to make educated clinical decisions.